The genetic factors of bilaterian evolution

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Title:Main Title: The genetic factors of bilaterian evolution
Description:Abstract: The Cambrian explosion was a unique animal radiation ~540 million years ago that produced the full range of body plans across bilaterians. The genetic mechanisms underlying these events are unknown, leaving a fundamental question in evolutionary biology unanswered. Using large-scale comparative genomics and advanced orthology evaluation techniques, we identified 157 bilaterian-specific genes. They include the entire Nodal pathway, a key regulator of mesoderm development and left-right axis specification; components for nervous system development, including a suite of G-protein-coupled receptors that control physiology and behaviour, the Robo-Slit midline repulsion system, and the neurotrophin signalling system; a high number of zinc finger transcription factors; and novel factors that previously escaped attention. Contradicting the current view, our study reveals that genes with bilaterian origin are robustly associated with key features in extant bilaterians, suggesting a causal relationship.
Responsible Party
Creators:Peter Heger (Author), Wen Zheng (Author), Anna Rottmann (Author), Kirsten A Panfilio (Author), Thomas Wiehe (Author)
Publisher:eLife
Publication Year:2020
Topic
CRC1211 Topic:Biology
Related Subproject:B3
Subjects:Keywords: Evolution, Data Management
Geogr. Information Topic:Biota
File Details
Filename:elife-45530-v2.pdf
Data Type:Data Paper - Research Paper
File Size:5.6 MB
Date:Issued: 16.07.2020
Mime Type:application/pdf
Data Format:PDF
Language:English
Status:Completed
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Download Permission:Free
General Access and Use Conditions:According to the CRC1211DB data policy agreement.
Access Limitations:According to the CRC1211DB data policy agreement.
Licence:[Creative Commons] Attribution 4.0 International (CC BY 4.0)
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Specific Information - Publication
Publication Status:Published
Review Status:Peer reviewed
Publication Type:Article
Article Type:Journal
Source:eLife
Volume:9
Number of Pages:41 (1 - 41)
Metadata Details
Metadata Creator:Yichen Zheng
Metadata Created:23.07.2021
Metadata Last Updated:27.01.2022
Subproject:B3
Funding Phase:1
Metadata Language:English
Metadata Version:V50
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