The structured coalescent in the context of gene copy number variation
This page lists all metadata that was entered for this dataset. You can download the dataset.
Feature
Citation
Citation Options
Identification
| Title: | Main Title: The structured coalescent in the context of gene copy number variation |
| Description: | Abstract: The Structured Coalescent was introduced to describe the coalescent process in spatially subdivided populations with migration. Here, we re-interpret migration routes of individuals in the original model as "migration routes" of single genes in tandemly arranged gene arrays. A gene copy may change its position within the array via unequal recombination. Hence, in a coalescent framework, two copies sampled from two chromosomes may coalesce only if they are at exactly homologous positions. Otherwise, one or multiple recombination events have to occur before they can coalesce, thereby increasing mean coalescence time and expected genetic diversity among the copies in a gene array. We explicitly calculate the transition probabilities on these routes backward in time. We simulate the structured coalescent with migration and coalescence rates informed by the unequal recombination process of gene copies. With this novel interpretation of population structure models we determine coalescence times and expected genetic diversity in samples of orthologous and paralogous copies from a gene family. As a case study, we discuss the site frequency spectrum of a small gene family in the two scenarios of high and of no gene copy number variation among individuals. These examples underline the significance of our model, since standard test-statistics may lead to misinterpretations when analyzing sequence data of multi-copy genes due to their different expected genetic diversity. |
| Identifier: | https://doi.org/10.1016/j.tpb.2023.08.001 (DOI) |
| Citation Advice: | Otto, M., & Wiehe, T. (2023). The structured coalescent in the context of gene copy number variation. Theoretical population biology, 154, 67–78. Advance online publication. https://doi.org/10.1016/j.tpb.2023.08.001 |
Responsible Party
| Creators: | Moritz Otto (Author), Thomas Wiehe (Author) |
| Funding Reference: | Deutsche Forschungsgemeinschaft (DFG): CRC 1211: Earth - Evolution at the Dry Limit |
| Publisher: | Theoretical Population Biology |
| Publication Year: | 2023 |
Topic
| CRC1211 Topic: | Biology |
| Related Subproject: | B6 |
| Subject: | Keyword: Population Genetics |
File Details
| Filename: | 1-s2.0-S0040580923000564-main.pdf |
| Data Type: | Text - Article |
| File Size: | 1.2 MB |
| Dates: | Issued: 30.08.2023 Submitted: 28.02.2023 |
| Mime Type: | application/pdf |
| Data Format: | |
| Language: | English |
| Status: | Completed |
Constraints
| Download Permission: | Free |
| General Access and Use Conditions: | According to the CRC1211DB data policy agreement. |
| Access Limitations: | According to the CRC1211DB data policy agreement. |
| Licence: | None |
Geographic
Specific Information - Publication
| Publication Status: | Published |
| Review Status: | Peer reviewed |
| Publication Type: | Article |
| Article Type: | Journal |
| Source: | ScienceDirect |
| Number of Pages: | 12 (67 - 78) |
Metadata Details
| Metadata Creator: | Moritz Otto |
| Metadata Created: | 22.11.2023 |
| Metadata Last Updated: | 22.11.2023 |
| Subproject: | B6 |
| Funding Phase: | 2 |
| Metadata Language: | English |
| Metadata Version: | V50 |
Metadata Export
| Metadata Schema: |
Dataset Statistics
| Page Visits: | 28 |
| Metadata Downloads: | 0 |
| Dataset Downloads: | 0 |
Dataset Activity
Feature
By downloading this dataset you accept the license terms of CRC1211DB Data Protection Statement
Adequate reference when this dataset will be discussed or used in any publication or presentation is mandatory. In this case please contact the dataset creator.
Adequate reference when this dataset will be discussed or used in any publication or presentation is mandatory. In this case please contact the dataset creator.
