Parthenogenomics: Insights on mutation rates and nucleotide diversity in parthenogenetic Panagrolaimus nematodes

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Title:Main Title: Parthenogenomics: Insights on mutation rates and nucleotide diversity in parthenogenetic Panagrolaimus nematodes
Description:Abstract: Asexual reproduction is assumed to lead to the accumulation of deleterious muta- tions, and reduced heterozygosity due to the absence of recombination. Panagrolaimid nematode species display different modes of reproduction. Sexual reproduction with distinct males and females, asexual reproduction through parthenogenesis in the genus Panagrolaimus, and hermaphroditism in Propanagrolaimus. Here, we compared genomic features of free-living nematodes in populations and species isolated from geographically distant regions to study diversity, and genome-wide differentiation under different modes of reproduction. We firstly estimated genome-wide sponta- neous mutation rates in a triploid parthenogenetic Panagrolaimus, and a diploid her- maphroditic Propanagrolaimus via long-term mutation accumulation lines. Secondly, we calculated population genetic parameters including nucleotide diversity, and fixa- tion index (FST) between populations of asexually and sexually reproducing nema- todes. Thirdly, we used phylogenetic network methods on sexually and asexually reproducing Panagrolaimus populations to understand evolutionary relationships be- tween them. The estimated mutation rate was slightly lower for the asexual popu- lation, as expected for taxa with this reproductive mode. Natural polyploid asexual populations revealed higher nucleotide diversity. Despite their common ancestor, a gene network revealed a high level of genetic differentiation among asexual popula- tions. The elevated heterozygosity found in the triploid parthenogens could be ex- plained by the third genome copy. Given their tendentially lower mutation rates it can be hypothesized that this is part of the mechanism to evade Muller's ratchet. Our findings in parthenogenetic triploid nematode populations seem to challenge com- mon expectations of evolution under asexuality.
Responsible Party
Creators:Laura Villegas (Author), Luca Ferreti (Author), Thomas Wiehe (Author), Ann-Marie Waldvogel (Author), Philipp Schiffer (Author)
Publisher:John Wiley & Sons Ltd
Publication Year:2024
CRC1211 Topic:Biology
Related Subproject:B8
Subject:Keyword: Population Genetics
File Details
Data Type:Data Paper - Published manuscript
File Size:4 MB
Date:Available: 07.01.2024
Mime Type:application/pdf
Data Format:PDF
Download Permission:Free
General Access and Use Conditions:According to the CRC1211DB data policy agreement.
Access Limitations:According to the CRC1211DB data policy agreement.
Licence:[Creative Commons] Attribution 4.0 International (CC BY 4.0)
Specific Information - Publication
Publication Status:Accepted
Review Status:Peer reviewed
Publication Type:Article
Article Type:Journal
Source:Ecology and Evolution
Source Website:
Number of Pages:14 (1 - 14)
Metadata Details
Metadata Creator:Laura Villegas
Metadata Created:22.01.2024
Metadata Last Updated:22.01.2024
Funding Phase:2
Metadata Language:English
Metadata Version:V50
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